{
 "signatures_denoised": {
  "Homeostatic": [
   "P2RY12",
   "CX3CR1",
   "TMEM119",
   "SALL1",
   "HEXB",
   "CSF1R",
   "TGFBR1",
   "MERTK",
   "ITGB5",
   "SPARC",
   "GPR34",
   "OLFML3",
   "SELPLG",
   "P2RY13",
   "ADGRB1",
   "KBTBD12",
   "RASGEF1C"
  ],
  "Homeostatic-GRID2+": [
   "GRID2",
   "PRDM11",
   "ADGRB3",
   "SYNDIG1",
   "DSCAM",
   "MED12L",
   "NAV2",
   "RASGEF1C",
   "TBC1D4",
   "USP6NL",
   "MAP4K4",
   "DOCK10",
   "RALGAPA2",
   "TBC1D9",
   "TBC1D12",
   "EVI5",
   "SNX13",
   "RAP1GAP2"
  ],
  "Pre-activated": [
   "P2RY12",
   "CX3CR1",
   "SERPINE1",
   "PELI2",
   "FOXP2",
   "INPP5D",
   "CARD11",
   "ID2",
   "NCKAP1L",
   "CSF3R",
   "PADI2",
   "PREX1",
   "TRPM2",
   "SWAP70",
   "GAB1",
   "RGS1",
   "CD83"
  ],
  "Inflammatory DAM": [
   "APOE",
   "CLEC7A",
   "ITGAX",
   "LGALS3",
   "SPP1",
   "AXL",
   "LPL",
   "CST7",
   "CD74",
   "TYROBP",
   "TREM2",
   "CD9",
   "CSF1",
   "CD63",
   "LAG3",
   "CD68",
   "CCL3",
   "CCL4",
   "TMEM163",
   "HAMP"
  ],
  "Lipid DAM / Lipid-droplet-accumulating microglia": [
   "GPNMB",
   "LGALS3",
   "FABP5",
   "LGALS1",
   "LILRB4",
   "CCL15",
   "ANXA5",
   "PLD3",
   "CD9",
   "CD36",
   "LPL",
   "APOE",
   "TREM2",
   "FABP4",
   "NPC1",
   "NPC2",
   "MSR1",
   "PLIN2",
   "APOC1",
   "PPARG",
   "MITF"
  ],
  "Ribosomal DAM 1": [
   "SYT1",
   "PCDH9",
   "LSAMP",
   "CADM2",
   "CALM1",
   "KCNIP4",
   "PEBP1",
   "RBFOX1",
   "CNTNAP2",
   "RPL39",
   "DYNLL1",
   "COXFA4",
   "MT-ATP6",
   "RPS27",
   "DLG2",
   "RTN3",
   "MT-ND1",
   "ATP5F1E",
   "RPL18A",
   "RPS18"
  ],
  "Ribosomal DAM 2": [
   "PLEKHA7",
   "MECOM",
   "OOEP",
   "ATP5F1E",
   "FTH1",
   "BAIAP2L1",
   "PLEKHA6",
   "BDNF-AS",
   "FTL",
   "NACA",
   "SLC27A4",
   "APOO",
   "SLC47A1",
   "ZNF90",
   "TXNRD1",
   "XPO5",
   "RPL19",
   "TMSB10",
   "UBA52",
   "TOMM7"
  ],
  "Activated Response Microglia (ARM)": [
   "HLA-DRB1",
   "HLA-DRB5",
   "CD74",
   "DKK2",
   "GPNMB",
   "SPP1",
   "APOE",
   "TREM2",
   "TYROBP",
   "ITGAX",
   "LGALS3",
   "CST7",
   "CTSS"
  ],
  "Interferon-Responsive Microglia (IRM)": [
   "IFI27",
   "IFITM3",
   "CCL2",
   "BST2",
   "IFIT3",
   "ISG15",
   "IFI16",
   "IRF7",
   "CXCL10",
   "OASL",
   "RTP4",
   "B2M",
   "STAT1",
   "IRF9",
   "IFIH1",
   "IFIT1",
   "IRF1",
   "IRF8",
   "ZBP1",
   "CH25H"
  ],
  "MHC-II-high": [
   "HLA-DRB1",
   "HLA-DRB5",
   "CD74",
   "CIITA",
   "HLA-A",
   "B2M",
   "CD86",
   "IL1B",
   "TNF",
   "HLA-DRA",
   "CD40",
   "NLRC5",
   "TAP1",
   "TAP2",
   "PSMB8",
   "PSMB9"
  ],
  "Proliferating / Cycling": [
   "MKI67",
   "TOP2A",
   "CENPE",
   "MCM5",
   "BIRC5",
   "CDK1",
   "CCNB2",
   "PCNA",
   "AURKB",
   "CENPF",
   "PLK1",
   "CDCA8",
   "CDCA3",
   "CDC20",
   "CCNA2",
   "CCNB1"
  ],
  "Disease-Inflammatory Macrophages (DIMs)": [
   "SLC2A3",
   "CD83",
   "CCL3",
   "CH25H",
   "NAMPT",
   "SRGN",
   "IRAK2",
   "HIF1A",
   "RGS1",
   "MCL1"
  ],
  "Border-Associated Macrophages (BAMs)": [
   "F13A1",
   "CD163",
   "MRC1",
   "MS4A7",
   "LYVE1",
   "FOLR2",
   "STAB1",
   "PF4",
   "CBR1",
   "CD209",
   "CD163L1",
   "CLEC10A"
  ],
  "Axon Tract-associated Microglia (ATM) / White-matter-associated (WAM)": [
   "ITGAX",
   "IGF1",
   "SPP1",
   "GPNMB",
   "LGALS3",
   "CD68",
   "CD9",
   "FABP5",
   "PLD3",
   "CTSL",
   "LGALS1",
   "LILRB4",
   "CD63",
   "CTSB"
  ],
  "Embryonic / Early-postnatal Microglia": [
   "SPI1",
   "CX3CR1",
   "FABP5",
   "MCM5",
   "CCND1",
   "DAB2",
   "MRC1",
   "MS4A7",
   "FN1",
   "CSF1R",
   "CD4",
   "RUNX1",
   "F13A1"
  ],
  "Neonatal CD11c+ / Proliferative-region-associated (PAM)": [
   "ITGAX",
   "IGF1",
   "SPP1",
   "GPNMB",
   "CLEC7A",
   "TREM2",
   "LGALS3",
   "CD68",
   "FABP5",
   "LPL",
   "CSF1",
   "MRC1",
   "CD74"
  ],
  "Transitional IFN-DAM": [
   "ISG15",
   "IFI44L",
   "IRF9",
   "IFITM3",
   "IRF7",
   "ZBP1",
   "CXCL10",
   "STAT1",
   "MX1",
   "OASL",
   "ISG20",
   "IFIT1",
   "IFIT2",
   "IFIT3",
   "APOE",
   "TREM2"
  ],
  "Advanced DAM (S100+)": [
   "HLA-DRB1",
   "HLA-DRB5",
   "CD74",
   "S100A6",
   "S100A8",
   "S100A9",
   "CCL15",
   "LGALS3",
   "CD63",
   "ITGAX",
   "CYBB",
   "TREM2",
   "APOE",
   "TYROBP"
  ],
  "Human MG-AD / GPNMB+ DAM-like state": [
   "GPNMB",
   "APOC1",
   "APOE",
   "TREM2",
   "CD9",
   "ITGAX",
   "SPP1",
   "MYO1E",
   "PPARG",
   "NUPR1",
   "CTSB",
   "CTSD",
   "GRN",
   "ASAH1",
   "LPL",
   "CD63"
  ],
  "Cytokine / Chemokine-enriched (CRM)": [
   "CCL2",
   "CCL3",
   "CCL4",
   "CXCL8",
   "IL1B",
   "TNF",
   "NFKBIA",
   "NFKB1",
   "CCL3L1",
   "CCL4L2"
  ],
  "Chronic-active MS rim microglia (MIMS-iron)": [
   "FTL",
   "FTH1",
   "CD163",
   "APOC1",
   "APOE",
   "GPNMB",
   "MSR1",
   "SPP1",
   "CD68",
   "ACSL1",
   "NAMPT",
   "SLC11A1"
  ],
  "ALS/FTLD cortical disease-associated microglia": [
   "CD68",
   "SPP1",
   "APOC1",
   "APOE",
   "FTL",
   "GPNMB",
   "LPL",
   "CD63",
   "MS4A6A",
   "MS4A7",
   "CD83",
   "HLA-DRA",
   "ITGAX",
   "TREM2"
  ],
  "Antigen-presenting / dendritic-like microglia (HLA-high II)": [
   "HLA-DRA",
   "HLA-DRB1",
   "HLA-DPA1",
   "CD74",
   "CIITA",
   "HLA-DQA1",
   "CD83",
   "LAMP3",
   "CCR7",
   "FLT3",
   "ZBTB46"
  ]
 },
 "dissociation_blocklist": [
  "ATF3",
  "BAG3",
  "BTG2",
  "CREM",
  "DNAJA1",
  "DNAJB1",
  "DUSP1",
  "DUSP2",
  "EGR1",
  "EGR2",
  "EGR3",
  "FOS",
  "FOSB",
  "HSP90AA1",
  "HSPA1A",
  "HSPA1B",
  "HSPA5",
  "HSPA8",
  "HSPB1",
  "HSPH1",
  "IER2",
  "IER3",
  "JUN",
  "JUNB",
  "JUND",
  "NR4A1",
  "NR4A2",
  "NR4A3",
  "RHOB",
  "SOCS3",
  "ZFP36",
  "ZFP36L1",
  "ZFP36L2"
 ],
 "note": "Use flat per-sub-state scoring (mean z of denoised up-genes); take argmax; roll up to umbrella via the hierarchy. Family-level accuracy 73% on 3 ALS datasets. Drop 'Stress/HSP' (artifact-only) from classification."
}